Current lab efforts focus on rationally generating substrate-specific inhibitors of the multi-substrate kinase, delta PKC (Qvit, J Am Chem Soc 2016 Qvit, Angewante 2016). The company was acquired by Amgen in 2012 and one of KAI's drug was approved in Europe (2016). Leon Chen (a graduate student from the lab) in 2002. The study was carried out by KAI Pharmaceuticals that was co-founded with Dr. A phase IIa study in humans demonstrated that one of the peptide inhibitors is efficacious in reducing cardiac damage in myocardial infarction patients. Importantly, these peptide regulators are useful as therapeutics in a variety of animal models of human diseases, including myocardial infarction and heart failure (Nature Review Drug Discovery, 2013). These peptide regulators of PKC identified the role of this family of enzymes in a number of cellular responses. This rational approach led to the discovery of the only highly selective protein kinase C (PKC) inhibitors and activators. Using rational approaches, we identify short peptide inhibitors of intracellular protein-protein interactions to interfere with signal transduction under basal and pathological conditions (Nature Biotechnology, 2008). We study how protein-protein interactions govern cell signaling (Science, 1995). There are several research areas: two use peptide inhibitors and two to small molecules.

We develop pharmacological agents and apply them to understand molecular and cellular events under basal and disease conditions using in vitro, in culture and in vivo models. We are a multi-disciplinary research lab that includes chemists, biochemists, biologists and physician scientists. Vice Provost for Undergraduate Education.

Office of Vice President for Business Affairs and Chief Financial Officer.Office of VP for University Human Resources.Stanford Woods Institute for the Environment.Stanford Institute for Economic Policy Research (SIEPR).Institute for Stem Cell Biology and Regenerative Medicine.Institute for Human-Centered Artificial Intelligence (HAI).Institute for Computational and Mathematical Engineering (ICME).Freeman Spogli Institute for International Studies.School of Earth, Energy and Environmental Sciences.

Daria restoration project season 1